Prevagen Side Effects – What You Must Know About Prevagen and Complaints, Uses, Dosage, Warnings


What Drug class is Prevagen in and what are Prevagen side effects?

prevagen side effects

Prevagen also known as Apoaequorin – prevagen side effects are based primarily on the main ingredient, called apoaequorin. Overall, side effects of this brain health supplement are minimal, although you should always speak to your doctor or health care professional before taking any supplement.

Below, we explore more of what you should know as far as Prevagen side effects, so you’re informed before taking this memory supplement.  

Prevagen Side Effects-Key Takeaways

  • Prevagen is a memory-improving supplement for healthy brain function and cognitive health
  • One of the primary active ingredients in Prevagen is called apoaequorin
  • Apoaequorin is a protein preparation that comes from jellyfish species and may help you have a sharper mind and boost your mental function
  • There is limited clinical research and scientific evidence on the long-term safety of Prevagen, but also no known major side effects
  • There have been a few user reports of more serious side effects stemming from Prevagen and apoaequorin

What is Prevagen?

First, before exploring the possible side effects of Prevagen, what is it?

Prevagen is a natural product available through retailers like Amazon that may help with mild memory loss associated with aging and general cognitive aging.

It is formulated with apoaequorin. People take Prevagen to help improve cognitive functioning and reduce any signs of cognitive impairment or a decline in memory they might experience. 

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This ingredient, which was originally discovered in jellyfish, may support cognitive function. It is patented for use by Quincy Bioscience.

Quincy Bioscience is located in Wisconsin, and they focus on creating products to help reduce mild memory loss and support healthy cognitive function.

In one particular study, adults who were over 40 years old took one Prevagen capsule a day for 90 days. They experienced improvements in different aspects of cognitive function, according to Quincy Bioscience.

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Prevagen first came onto the marketplace in 2007.

Apoaequorin protein comes specifically from glowing luminescent jellyfish. When this protein is exposed to calcium, it binds, producing the blue light seen in the jellyfish.

The idea behind using it in a memory supplement for cognitive decline like Prevagen is that it has a similar structure to calcium-binding protein found in humans. Some evidence suggests it could help regulate calcium levels in the human brain, reducing mental decline and memory loss.

Calcium is relevant to cognition and memory because it’s an important messenger molecule. It’s thought to be related to neuron cell death and aging. That can mean it plays a role in age-related cognitive and memory declines.

Prevagen also contains 50 mcg (2000 IU) of vitamin D, an important vitamin especially for older people or people who don’t get a lot of sunlight. Vitamin D is also helpful for many chronic conditions. 

In the 2020 Pharmacy Times Survey of pharmacists’ recommendations for the best over-the-counter memory support, Prevagen was number one. Seventy-three percent of surveyed pharmacists said it was their top pick among OTC memory supplements. 

No supplement is considered among the FDA-approved drugs. The FDA doesn’t regulate supplements, so you have to do your own research before trying them and you often can’t find a database of adverse event reports, allergic reactions or detailed concerns for safety. 

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Prevagen Controversy

While Prevagen does have great reviews and some strong anecdotal evidence for its use, that doesn’t tell the whole story. It has been the subject of controversy including potential false advertising claims in recent years. 

We wanted to learn more about the possible adverse effects of this supplement promising to fight age-related mental decline and promote healthy brain activity. 

prevagen reviews prevagen ingredients

First, we did mention the positive results of a double-blind study above. Critics have said that when they looked at that trial, they didn’t see any statistically significant results observed over the entire study population for any cognitive tasks in the study. Supposedly, the trial also failed to compare the protein apoaequorin and control groups.

Opponents of the company’s safety assessment and claims say that what’s actually being touted as evidence is an after-the-fact analysis of study participants’ subgroups. There has been no further research beyond this original study to verify the supposed claims. The company may have taken one bit of inconclusive information from a study and then used that to validate their hypothesis.

There is another issue as well, which is bioavailability.

Bioavailability is something we talk about a lot when ranking and reviewing supplements. If something isn’t highly bioavailable, it’s going to have limited benefits for you because your body can’t absorb and utilize what you’re taking.

There is research showing Prevagen may degrade quickly during digestion. That means that the actual apoaequorin might not be able to make it past the blood-brain barrier, so that would limit the potential psychological benefits.

In 2017, the Federal Trade Commission (FTC) and the Attorney General of New York State charged the Quincy Bioscience Company was making unsubstantiated and false claims about Prevagen’s effectiveness.

Prevagen ingredients side effects

However, the court ruled in favor of Quincy Bioscience, saying the concept of looking at subgroups is widely used in data interpretation in dietary supplements.

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What Are the Potential Side Effects of Prevagen?

While the evidence is mixed as far as whether or not this apoaequorin product is effective, we couldn’t find anything suggesting it’s dangerous or has especially harmful side effects.

MedicineNet describes it as being possibly safe when taken by mouth. You should always follow the dosage instructions, which means taking up to 10 mg a day.

Some of the user-reported Prevagen common side effects have included:

  • Dizziness
  • Headache
  • Nausea
  • Problems sleeping
  • Anxiety
  • Cardiovascular problems  (especially when taken in doses over 10mg per day)
    • Chest pain
    • Hypertension
    • Irregular heart rate

Rarely, some Prevagen side effects have occurred related to the heart and nervous system. Even so, we don’t know for sure that these are Prevagen side effects. Any number of other factors could have caused these and there’s insufficient evidence to say that Prevagen causes heart-related adverse effects. 

Apoaequorin is POSSIBLY SAFE when taken by mouth appropriately. A 10 mg dose of a specific apoaequorin product (Prevagen, Quincy Bioscience) has been used safely for up to 90 days. No clinical research has adequately evaluated side effects caused by apoaequorin.

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Some people who have taken apoaequorin have reported potential side effects to a manufacturer of the product. Some of the most commonly reported side effects were headache, dizziness, and nausea. Others less common events were memory problems, difficulty sleeping, and anxiety.

There have also been a smaller number of reports of more serious potential side effects such as heart and nervous system-related events – prevagen does it work?

It is important to understand that although these events occurred while people took this product, this does not necessarily mean that the product caused these events.

There is not enough information about these potential side effects to know if apoaequorin was the actual cause of these side effects.

We don’t have a lot of information on a larger scale to determine specifically what Prevagen side effects could be.

Along with the side effects of Prevagen, we also looked at whether there were any known interactions with other medicines. We couldn’t find any at this time. Always ask your doctor before you take any supplement, including Prevagen. This is especially true if you take any prescription or over-the-counter medicines already.

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In addition to officially recorded Prevagen side effects, we also looked at Amazon to see if the users there reported any.

One fear that someone expressed we found interesting was the worry about the vitamin D the supplement contains. Vitamin D is very important, especially as we age.

However, too much vitamin D can be harmful. If you’re taking Prevagen and getting vitamin D elsewhere, you could be at risk of toxicity.

Vitamin D3 is fat-soluble. It doesn’t leave your body if you take too much, as vitamin C does as an example. Instead, too much vitamin D3 can buildup in your body’s fat cells and lead to toxicity issues like hypercalcemia.

Some United States reviews on Amazon that mention Prevagen side effects cite “incapacitating dizziness” and similar effects. 


The appropriate dose of apoaequorin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for apoaequorin (in children/in adults).

Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Final Thoughts:

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Potential Prevagen side effects and the possibility for adverse events are likely minimal. However, there are other problems with this product promoted to help brain performance to be aware of. Prevagen has little research to verify its effectiveness for any memory loss conditions or even mild impairment of cognition. It’s an expensive supplement that doesn’t have any benefits for a lot of people.

Possible Prevagen side effects and common events might include headache, nausea, and dizziness. Talk to your healthcare provider before taking any supplement or following any health tips. 

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